منابع مشابه
Cell biology of mechanotransduction in inner-ear hair cells
The cloning of deafness genes, especially those for Usher syndrome, has helped to identify a variety of structural proteins involved in the development and function of hair-cell stereocilia. These include novel cadherins, a handful of myosin motors, and scaffolding proteins. Yet a new understanding of these proteins has upended the orthodox view of mechanosensation by hair cells.
متن کاملAutoimmune Inner Ear Disease- A Clinical Viewpoint
Recent developments in medicine have given us a better insight into a group of disorders known as autoimmune diseases. In particular, advances have occurred in our understanding of the Autoimmune Inner Ear Disease (AIED). In this article, the authors review the different postulated theories in the pathogenesis of this disease. The clinical presentation, the available para-clinical diagnostic to...
متن کاملBiomechanics in the Inner Ear
The elongation and contraction of outer hair cells (OHCs) greatly contribute to the high sensitivity and frequency selectivity of the mammalian inner ear. The motility of OHCs is believed to be based on the conformational changes of the motor protein prestin in the plasma membrane of OHCs. In the present study, four lines of research on the inner ear were conducted. First, the mechanism by whic...
متن کاملInside the inner ear
There are dozens of different myosin isozymes, though it's not clear why cells require such a diversity. These images of fluorescently-labelled hair cells from the inner ears of frog, guinea pig and mouse show the localization of actin (red at top left and bottom right) and of four different forms of myosin (green, except at bottom left, where myosin VI is labelled in red). Hair cells are the r...
متن کاملSphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?
Hearing loss is one of the most prevalent conditions around the world, in particular among people over 60 years old. Thus, an increase of this affection is predicted as result of the aging process in our population. In this context, it is important to further explore the function of molecular targets involved in the biology of inner ear sensory cells to better individuate new candidates for the...
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ژورنال
عنوان ژورنال: Equilibrium Research
سال: 2007
ISSN: 0385-5716,1882-577X
DOI: 10.3757/jser.66.41